Global Small Molecule API Market 2020-2027 by Source (Synthetic, Semi-synthetic, Natural), Type (Standard, HPAPI), Therapeutic Area, Application (Clinical, Commercial), Manufacturer Type (Pharma, CMO), and Region: Trend Forecast and Growth Opportunity
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Global small molecule active pharmaceutical ingredient (API) market will reach $266.2 billion by 2027, growing by 7.3% annually over 2020-2027 owing to increasing incidences of diseases, development of companies engaged in the manufacturing of small molecule APIs, the increasing technological developments in manufacturing sector, and surge in healthcare expenditure amid COVID-19 pandemic.
Highlighted with 85 tables and 85 figures, this 165-page report “Global Small Molecule API Market 2020-2027 by Source (Synthetic, Semi-synthetic, Natural), Type (Standard, HPAPI), Therapeutic Area, Application (Clinical, Commercial), Manufacturer Type (Pharma, CMO), and Region: Trend Forecast and Growth Opportunity” is based on a comprehensive research of the entire global small molecule API market and all its sub-segments through extensively detailed classifications. Profound analysis and assessment are generated from premium primary and secondary information sources with inputs derived from industry professionals across the value chain. The report is based on studies on 2017-2019 and provides estimate for 2020 and forecast from 2021 till 2027 with 2019 as the base year. (Please note: The report will be updated before delivery so that the latest historical year is the base year and the forecast covers at least 5 years over the base year.)
In-depth qualitative analyses include identification and investigation of the following aspects:
• Market Structure
• Growth Drivers
• Restraints and Challenges
• Emerging Product Trends & Market Opportunities
• Porter’s Fiver Forces
The trend and outlook of global market is forecast in optimistic, balanced, and conservative view by taking into account of COVID-19. The balanced (most likely) projection is used to quantify global small molecule API market in every aspect of the classification from perspectives of Source, Type, Therapeutic Area, Application, Manufacturer Type, and Region.
Based on Source, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2017-2027 included in each section.
• Synthetic API
o Branded Synthetic API
o Generic Synthetic API
• Semi-synthetic API
• Natural Origin
Based on Type, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2017-2027 included in each section.
• Standard API
• High Potency API (HPAPI)
o Branded HPAPI
o Generic HPAPI
Based on Therapeutic Area, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2017-2027 included in each section.
• Infectious Diseases
• Oncology
• Ophthalmology
• Cardiovascular Disorders
• Central Nervous System
• Respiratory Disorders
• Metabolic Diseases
• Other Applications
Based on Application, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2017-2027 included in each section.
o Clinical Use
o Commercial Use
Based on Manufacturer Type, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2017-2027 included in each section.
• Pharmaceutical Companies (also breakdown by region)
• CMOs (also breakdown by region)
Geographically, the following regions together with the listed national/local markets are fully investigated:
• APAC (Japan, China, South Korea, Australia, India, and Rest of APAC; Rest of APAC is further segmented into Malaysia, Singapore, Indonesia, Thailand, New Zealand, Vietnam, Taiwan, and Philippines)
• Europe (Germany, UK, France, Spain, Italy, Russia, Rest of Europe; Rest of Europe is further segmented into Netherlands, Switzerland, Poland, Sweden, Belgium, Austria, Ireland, Norway, Denmark, and Finland)
• North America (U.S., Canada, and Mexico)
• South America (Brazil, Chile, Argentina, Rest of South America)
• MEA (UAE, Saudi Arabia, South Africa)
For each aforementioned region and country, detailed analysis and data for annual revenue ($ bn) are available for 2017-2027. The breakdown of all regional markets by country and split of key national markets by Type, Therapeutic Area, and Manufacturer Type over the forecast years are also included.
The report also covers current competitive scenario and the predicted trend; and profiles key vendors including market leaders and important emerging players.
Key Players (this may not be a complete list and extra companies can be added upon request):
Aurobindo Pharma Ltd.
Cambrex Corporation
Catalent, Inc.
Dr. Reddy's Laboratories Ltd.
GlaxoSmithKline plc
Lonza Group
Merck & Co., Inc.
Mylan N.V.
Novartis AG
Pfizer Inc.
Sun Pharmaceutical Industries Ltd.
Teva Pharmaceutical Industries Ltd.
Wuxi AppTec Co., Ltd.
(Please note: The report will be updated before delivery so that the latest historical year is the base year and the forecast covers at least 5 years over the base year.)
1 Introduction 8
1.1 Industry Definition and Research Scope 8
1.1.1 Industry Definition 8
1.1.2 Research Scope 9
1.2 Research Methodology 12
1.2.1 Overview of Market Research Methodology 12
1.2.2 Market Assumption 13
1.2.3 Secondary Data 13
1.2.4 Primary Data 13
1.2.5 Data Filtration and Model Design 15
1.2.6 Market Size/Share Estimation 16
1.2.7 Research Limitations 17
1.3 Executive Summary 18
2 Market Overview and Dynamics 21
2.1 Market Size and Forecast 21
2.1.1 Impact of COVID-19 on World Economy 22
2.1.2 Impact of COVID-19 on the Market 24
2.2 Major Growth Drivers 26
2.3 Market Restraints and Challenges 29
2.4 Emerging Opportunities and Market Trends 32
2.5 Porter’s Fiver Forces Analysis 36
3 Segmentation of Global Market by Source 40
3.1 Market Overview by Source 40
3.2 Synthetic API 42
3.2.1 Branded Synthetic API 43
3.2.2 Generic Synthetic API 44
3.3 Semi-synthetic API 45
3.4 Natural Origin 46
4 Segmentation of Global Market by Type 47
4.1 Market Overview by Type 47
4.2 Standard API 49
4.3 High Potency API (HPAPI) 50
4.3.1 Branded HPAPI 51
4.3.2 Generic HPAPI 52
5 Segmentation of Global Market by Therapeutic Area 53
5.1 Market Overview by Therapeutic Area 53
5.2 Infectious Diseases 55
5.3 Oncology 56
5.4 Ophthalmology 57
5.5 Cardiovascular Disorders 58
5.6 Central Nervous System 59
5.7 Respiratory Disorders 60
5.8 Metabolic Diseases 61
5.9 Other Applications 62
6 Segmentation of Global Market by Application 63
6.1 Market Overview by Application 63
6.2 Clinical Use 65
6.3 Commercial Use 66
7 Segmentation of Global Market by Manufacturer Type 67
7.1 Market Overview by Manufacturer Type 67
7.2 Pharmaceutical Companies 69
7.3 CMOs 71
8 Segmentation of Global Market by Region 73
8.1 Geographic Market Overview 2020-2027 73
8.2 North America Market 2020-2027 by Country 77
8.2.1 Overview of North America Market 77
8.2.2 U.S. 80
8.2.3 Canada 84
8.2.4 Mexico 86
8.3 European Market 2020-2027 by Country 88
8.3.1 Overview of European Market 88
8.3.2 UK 91
8.3.3 France 93
8.3.4 Germany 95
8.3.5 Spain 97
8.3.6 Italy 99
8.3.7 Russia 101
8.3.8 Rest of European Market 103
8.4 Asia-Pacific Market 2020-2027 by Country 105
8.4.1 Overview of Asia-Pacific Market 105
8.4.2 China 108
8.4.3 Japan 110
8.4.4 India 113
8.4.5 Australia 115
8.4.6 South Korea 117
8.4.7 Rest of APAC Region 119
8.5 South America Market 2020-2027 by Country 121
8.5.1 Argentina 124
8.5.2 Brazil 126
8.5.3 Chile 128
8.5.4 Rest of South America Market 130
8.6 MEA Market 2020-2027 by Country 131
8.6.1 UAE 134
8.6.2 Saudi Arabia 136
8.6.3 South Africa 138
8.6.4 Other National Markets 140
9 Competitive Landscape 141
9.1 Overview of Key Vendors 141
9.2 New Product Launch, Partnership, Investment, and M&A 144
9.3 Company Profiles 145
Aurobindo Pharma Ltd. 145
Cambrex Corporation 147
Catalent, Inc. 148
Dr. Reddy's Laboratories Ltd. 149
GlaxoSmithKline plc 150
Lonza Group 151
Merck & Co., Inc. 152
Mylan N.V. 153
Novartis AG 154
Pfizer Inc. 155
Sun Pharmaceutical Industries Ltd. 156
Teva Pharmaceutical Industries Ltd. 157
Wuxi AppTec Co., Ltd. 158
10 Investing in Global Market: Risk Assessment and Management 159
10.1 Risk Evaluation of Global Market 159
10.2 Critical Success Factors (CSFs) 162
Related Reports and Products 165
Research Methodology:
Small Molecule API Market Size Estimation
To estimate market size and trends, we use a combination of top-down and bottom-up methods. This allows us to evaluate the market from various perspectives—by company, region, product type, and end users.
Our estimates are based on actual sales data, excluding any discounts. Segment breakdowns and market shares are calculated using weighted averages based on usage rates and average prices. Regional insights are determined by how widely a product or service is adopted in each area.
Key companies are identified through secondary sources like industry reports and company filings. We then verify revenue estimates and other key data points through primary research, including interviews with industry experts, company executives, and decision-makers.
We take into account all relevant factors that could influence the market and validate our findings with real-world input. Our final insights combine both qualitative and quantitative data to provide a well-rounded view. Please note, these estimates do not account for unexpected changes such as inflation, economic downturns, or policy shifts.
Data Source
Secondary Sources
This study draws on a wide range of secondary sources, including press releases, annual reports, non-profit organizations, industry associations, government agencies, and customs data. We also referred to reputable databases and directories such as Bloomberg, Wind Info, Hoovers, Factiva, Trading Economics, Statista, and others. Additional references include investor presentations, company filings (e.g., SEC), economic data, and documents from regulatory and industry bodies.
These sources were used to gather technical and market-focused insights, identify key players, analyze market segmentation and classification, and track major trends and developments across industries.
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Primary Sources
As part of our primary research, we interviewed a variety of stakeholders from both the supply and demand sides to gather valuable qualitative and quantitative insights.
On the supply side, we spoke with product manufacturers, competitors, industry experts, research institutions, distributors, traders, and raw material suppliers. On the demand side, we engaged with business leaders, marketing and sales heads, technology and innovation directors, supply chain executives, and end users across key organizations.
These conversations helped us better understand market segmentation, pricing, applications, leading players, supply chains, demand trends, industry outlook, and key market dynamics—including risks, opportunities, barriers, and strategic developments.
Key Data Information from Primary Sources
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